Can Ambien cause high cholesterol? As we all know, Ambien is a sleeping medication used for treating insomnia. Thus, it helps people have a nice sleep of 8 hours. However, people abusing this medication to achieve Ambien high are at a greater risk of suffering from high cholesterol. Since sleep plays a vital role in affecting a patient’s cholesterol as both sleep and high cholesterol could be connected. Abusing Ambien could cause the patient having a problem in sleeping and sleeping less than 6 hours or more than 8 hours exposes the patient at greater risks of having high cholesterol.