Cenforce D 100+60 mg varies from patient to patient, making it essential to consult your doctor for the correct dose tailored to your specific condition. Important considerations when taking this medication. Consume Cenforce with a glass of water 30 minutes to 1 hour before engaging in sexual activity. The medication typically takes effect within one to three hours after ingestion. Avoid high-fat meals when taking this medication, as it may affect its efficacy.