What are the risks of taking omeprazole for acid reflux over extended periods? Long-term use of omeprazole, a proton pump inhibitor (PPI), can lead to several health risks, including nutrient deficiencies (such as vitamin B12 and magnesium), increased risk of bone fractures, kidney disease, and gut infections due to reduced stomach acid. Prolonged use may also cause rebound acid hypersecretion, making acid reflux symptoms worse once the medication is stopped. While omeprazole can be effective for managing acid reflux, it should be used under medical supervision, and lifestyle modifications should be considered as part of treatment. For expert psychiatric guidance on managing stress-related digestive issues, visit https://www.delhimindclinic.com/ or explore top psychiatrists at https://www.bestpsychiatristsindelhi.com/.