When you are facing intense pain, understanding which drug is most effective for you. In here, Oxycodone vs oxymorphone are common comparison medications for those directly for serious pain management. Both drugs are very powerful opioids, but both work slightly differently. Oxycodone is mostly used to treat moderate to severe pain, and it is known for its fast relief availability for medications that combine with other drugs. On the other hand, oxymorphone is slightly stronger than other opioids; it is used when other drugs do not control pain.