How can Adderall cause erectile dysfunction in men? Get to know the reason behind it and what to seek before using Adderall. Adderall is a drug that is commonly prescribed to treat attention-deficit hyperactivity disorder (ADHD) and occasionally narcolepsy. While the medication can be helpful, it does have many side effects, some of which can impact your sexual health. Some people with a penis experience Adderall erectile dysfunction (ED). Other potential side effects include a decreased interest in sex.