Oxycodone and fentanyl are both powerful opioid painkillers, but they differ in strength, form, and usage. Fentanyl is significantly more potent—about 50 to 100 times stronger than morphine, used mainly for severe, chronic pain or during surgery, often in patches or injections. Oxycodone is typically prescribed for moderate to severe pain and is available in tablets or capsules. Fentanyl has a higher risk of overdose, especially when misused, due to its potency. Both drugs carry risks of dependence, tolerance, and addiction. Medical supervision is crucial for safe use, particularly with fentanyl, due to its rapid and intense effects.