Get to know the distinct points of difference between Xanax vs Adderall. Xanax (alprazolam) is a fast-acting benzodiazepine that enhances GABA activity to induce calm. In contrast, Adderall—a stimulant comprising amphetamine salts—boosts dopamine and norepinephrine to increase alertness and focus. Their opposing effects (depressant vs. stimulant) mean combining them can blunt their actions and lead to unpredictable outcomes. Using both raises the risk of addiction, adverse reactions, or overdose, and requires careful medical oversight. Always consult a healthcare provider before considering concurrent use of these medications.