Tramadol 37.5/325 mg is a combination medication that contains two active ingredients: tramadol hydrochloride (37.5 mg) and acetaminophen (325 mg). It is used to treat moderate to moderately severe pain and is available by prescription. This combination leverages the effects of both an opioid-like analgesic (tramadol) and a non-opioid pain reliever and fever reducer (acetaminophen) to provide effective and balanced pain control.