Both Oxycodone and OxyContin are potent opioids used to manage moderate to severe pain, but they differ primarily in how they release the drug and how they are used in treatment. Oxycodone (immediate-release) is ideal for short-term, acute pain management, while OxyContin (extended-release) is better suited for chronic, ongoing pain management. Due to their potential for addiction and overdose, both should be used only under strict medical supervision.