Bupropion and Adderall are sometimes prescribed together to manage co-occurring ADHD and depression. Adderall, a stimulant, improves focus and attention, while Bupropion, an atypical antidepressant, boosts mood and energy. The combination can be effective, especially when one condition worsens the other. However, both medications affect dopamine and norepinephrine levels, increasing the risk of side effects like anxiety, insomnia, or elevated blood pressure.