Adderall and Vyvanse are both stimulant medications used to treat ADHD, but they differ in formulation and how they work. Adderall contains a mix of amphetamine salts and acts quickly, making it suitable for flexible dosing. Vyvanse is a prodrug, meaning it must be metabolized by the body to become active, leading to a slower onset and smoother, longer-lasting effect. Vyvanse may have a lower abuse potential due to this delayed activation.