Oxycodone and Percocet are both prescription pain medications used to manage moderate to severe pain, but they differ in composition and effects. Oxycodone is an opioid analgesic taken alone, while Percocet combines oxycodone with acetaminophen, offering added pain relief. Percocet’s combination can enhance effectiveness but increases the risk of liver damage from acetaminophen overdose. Both carry opioid-related risks, including dependence, tolerance, respiratory depression, and potential for misuse. Patients should follow dosage instructions carefully, avoid alcohol, and consult their doctor before switching medications. Understanding the differences in composition, potency, and safety helps patients and healthcare providers choose the most appropriate pain management plan while minimizing side effects and health risks.