Percocet and Norco are both prescription painkillers that combine opioids with acetaminophen to treat moderate to severe pain. Percocet contains oxycodone, while Norco contains hydrocodone, making them slightly different in their potency and duration of action. Oxycodone (Percocet) is generally considered stronger than hydrocodone (Norco). Both medications carry risks of dependence, addiction, and side effects like drowsiness, constipation, nausea, and dizziness. However, Percocet may cause more pronounced respiratory depression. Both should be used cautiously and under medical supervision due to their potential for abuse and overdose.