Oxycodone and Roxicodone are prescription opioid medications used to manage moderate to severe pain, but they differ mainly in formulation. Oxycodone is the active opioid ingredient found in various products, including both immediate-release (IR) and extended-release (ER) versions. Roxicodone is a brand name for immediate-release oxycodone, designed to provide faster pain relief for short periods. Because it acts quickly, Roxicodone may be used for sudden or breakthrough pain, while ER oxycodone offers longer-lasting control. Both medications carry risks of dependence, overdose, and side effects, so they must be used exactly as prescribed under medical supervision.