Hydrocodone and oxycodone are prescription opioid medications used to treat moderate to severe pain, but they differ in strength, formulations, and typical uses. Oxycodone is generally considered slightly stronger and is available in both immediate-release and extended-release forms, offering options for short- or long-lasting pain control. Hydrocodone is often combined with acetaminophen in products like Norco, making it more common for short-term or post-surgical pain. Both medications work by binding to opioid receptors to reduce pain but carry risks such as dependence, constipation, drowsiness, and respiratory depression. The choice between them depends on pain severity, duration, and medical guidance.