MOTS-c is an emerging mitochondrial-derived peptide gaining attention for its potential role in supporting healthier metabolism, improved energy regulation, and cardiovascular resilience. Early research suggests that MOTS-c may help the body respond more efficiently to metabolic stress, enhance glucose utilization, and promote better cellular performance. Its possible influence on heart and vascular function through improved metabolic balance, reduced inflammation, and enhanced cellular protection positions MOTS-c as an exciting area of scientific exploration. This overview highlights the latest insights into how MOTS-c may contribute to metabolic health and cardiovascular support in ongoing research.