Oxycodone and oxymorphone are opioid medications used to treat moderate to severe pain, but they differ in potency, metabolism, and clinical use. Oxycodone is commonly prescribed and available in immediate- and extended-release forms, offering versatile dosing and broader use for acute and chronic pain. Oxymorphone is significantly stronger, typically reserved for patients who need potent, long-acting pain control or who are tolerant to other opioids. It has a faster onset but a higher risk of side effects due to its potency. Both carry risks of dependence, overdose, and respiratory depression and must be used under medical supervision.