Buy Percocet 10-325 Online combines oxycodone (10 mg), an opioid pain reliever, with acetaminophen (325 mg), which enhances pain control and reduces fever. Physicians may prescribe this strength for short-term management of moderate to severe pain, such as after surgery or significant injury. Because oxycodone can cause dependence and other serious effects, Percocet is a controlled medication that requires careful medical supervision.