Oxycodone and Norco are prescription medications used to manage moderate to severe pain, but they differ in composition and use. Oxycodone is a pure opioid, while Norco combines oxycodone with acetaminophen, which can enhance pain relief. Norco may provide more effective pain control for certain conditions due to this combination, but it also carries a risk of liver damage if acetaminophen is overused. Both medications have potential side effects such as drowsiness, nausea, and risk of dependence or misuse. Choosing between them depends on pain severity, individual health factors, and guidance from a healthcare professional to ensure safe and effective treatment.