Oxycodone and codeine are opioid pain medications used to treat moderate to severe pain, but they differ in strength and medical use. Oxycodone is a stronger opioid, often prescribed for severe or chronic pain, while codeine is milder and sometimes combined with other medications like acetaminophen for moderate pain. Both drugs carry risks of dependence, misuse, and side effects such as drowsiness, nausea, and constipation. Codeine’s effectiveness can vary due to genetic differences in metabolism. Choosing the right medication depends on pain severity, medical history, and professional guidance. Proper use under a healthcare provider’s supervision is essential for safety and effectiveness.