Oxycodone and Vicodin are prescription opioid pain relievers used for moderate to severe pain, but they differ in formulation and potency. Oxycodone is a standalone opioid available in immediate and extended release forms. Vicodin is a combination of hydrocodone and acetaminophen. Oxycodone is generally considered stronger and may be prescribed when pain is more intense. Both can cause side effects such as drowsiness, nausea, and constipation, and both carry risks of dependence. Clinicians choose between them based on pain severity, patient response, safety factors, and treatment goals. Careful medical supervision helps balance benefits with risks for appropriate pain management decisions.