Hydrocodone and Percocet are prescription opioid medications used to treat moderate to severe pain, but they differ in composition and strength. Hydrocodone is often combined with acetaminophen and is commonly prescribed for ongoing pain management. Percocet contains oxycodone and acetaminophen and is generally considered stronger, making it more suitable for severe pain. Both medications work by altering how the brain perceives pain and can cause side effects such as drowsiness, nausea, and constipation. Because both carry risks of dependence and overdose, healthcare providers carefully evaluate pain severity, patient history, and safety factors when choosing the most appropriate treatment option.