How can Adderall cause erectile dysfunction in men? Get to know the reason behind it and what to seek before using Adderall. Adderall (amphetamine/dextroamphetamine) can cause erectile dysfunction (ED) and other sexual side effects in some people with ADHD, often due to its stimulant effects on blood flow and neurotransmitters, but these issues are usually manageable and temporary, with solutions like dosage adjustments or switching medications available through your doctor.