What STDs Cause Erectile Dysfunction include sexually transmitted infections(STIs) mainly Chlamydia Infections and Gonorrhoea Infections. Certain STIs like Chlamydia, Gonorrhea, HIV, and Hepatitis can cause erectile dysfunction (ED) by infecting the prostate (prostatitis) or other reproductive glands, disrupting blood flow and function. Treatment involves antibiotics for bacterial STIs and antiviral medications for viruses like HIV/Hepatitis, alongside managing the underlying inflammation, with ED often resolving once the infection is cleared.