The article explores the biological mechanisms that drive peptide therapy, focusing on how semaglutide influences appetite regulation, satiety signaling, gastric emptying, and metabolic efficiency through its interaction with GLP-1 pathways. These processes are central to ongoing scientific investigations into obesity, insulin sensitivity, and long-term metabolic balance. Beyond its core mechanisms, the discussion places semaglutide within the broader landscape of peptide research, examining how peptide-based approaches differ from traditional weight-loss strategies. By targeting hormonal signaling rather than relying solely on caloric restriction or stimulatory pathways, peptide therapy represents a shift toward more precise, physiology-driven models of weight regulation. The article also highlights how researchers are studying semaglutide’s role in energy homeostasis, fat metabolism, and behavioral aspects of appetite control.