This comprehensive article examines the biological foundations and scientific potential of the sermorelin peptide, a synthetic analog of growth hormone-releasing hormone (GHRH). It explores how sermorelin stimulates endogenous growth hormone release via the GH/IGF-1 axis, its metabolic and cellular implications in research, and emerging investigations into its roles in neuroprotection, immune modulation, and broader endocrine pathways. The piece also underscores key considerations for researchers studying the peptide’s effects on development, metabolism, and systemic health.