Kisspeptin-10 is a biologically active decapeptide derived from the KISS1 gene that continues to attract significant research interest in 2025, particularly for its central role in neuroendocrine signaling. Ongoing studies focus on its interaction with the GPR54 (KISS1R) receptor and its regulatory influence on gonadotropin-releasing hormone (GnRH) secretion within the hypothalamic–pituitary–gonadal (HPG) axis. These investigations have helped clarify how Kisspeptin-10 contributes to reproductive hormone regulation, pubertal development, and feedback mechanisms involved in endocrine homeostasis.