Compare Gabapentin vs Tramadol to learn their usage, working mechanisms and interactions. Explore, which is better Gabapentin or Tramadol. Gabapentin and Tramadol represent two significant pillars in the world of pain management. The widespread use and popularity of these prescription drugs/pain medications are a testament to their effectiveness in managing a variety of pain types. Tramadol, classified as an opioid analgesic, is primarily used for moderate to severe pain, often post-surgery or for chronic conditions like arthritis. Gabapentin, initially developed for epilepsy, has found extensive use in treating neuropathic pain conditions, such as diabetic neuropathy and postherpetic neuralgia.