Can you Take Lunesta and Xanax Together? InteExplore, can you take Lunesta and Xanax together? Compare, & know Xanax and Lunesta interaction, potential risks, and effectiveness. Like most drugs, Lunesta may cause mild to serious side effects. Side effects may vary slightly depending on the dose you’re prescribed. The lists below contain some of the more common side effects Lunesta may cause but don’t include all possible side effects.ractions & Side Effects