Understand, can you mix Ibuprofen and Alcohol? Get knowledge on the effects of Alcohol and ibuprofen on health to avoid addiction. Ibuprofen (Advil, Motrin) is one of the most popular nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are a group of medications that are commonly taken to treat pain and inflammation. Ibuprofen comes in many different dosage forms and is available with a prescription and over the counter (OTC). Since the medication is so widely available, people sometimes wonder if it’s OK to drink alcohol if you’re taking ibuprofen. The short answer is no, it’s not recommended.