Gabapentin is one of the most common uses for the drug. It quiets the chemical burn the disc causes when it touches the nerve.Long-term gabapentin use can lead to dependency, withdrawal and potential cognitive impairments like memory issues, reduced executive function, and an increased risk of dementia, particularly with long-term, high-dose usage. Other potential long-term effects include unexplained weight gain, swelling,and chronic mood disturbances like depression.