Oxycodone and OxyContin are both powerful opioid pain medications derived from the same active ingredient, oxycodone, but they differ significantly in their formulation and release mechanisms. OxyContin is better because it provides consistent, for long lasting relief without needing to take medication every 4 hours. Some side effects of Oxycodone including Difficultyto take breathing and Signs of an allergic reaction.Some side effects of OxyContin such as Cardiovascular Issues and Physical Weakness, etc.