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O tratamento cirúrgico da talassemia consiste na esplenectomia (remoção cirúrgica do baço). O baço aumenta de tamanho e se torna mais ativo devido à destruição excessiva e defeituosa de hemácias. A esplenectomia é realizada quando o aumento anormal do baço causa sintomas dolorosos ou interfere na produção de células sanguíneas. A esplenectomia pode reduzir potencialmente a necessidade de transfusões de sangue, uma vez que a ação de filtragem do baço sobre as células sanguíneas danificadas é eliminada. Em certas situações, a cirurgia pode incluir transplante de medula óssea ou de células-tronco para curar a doença, substituindo a medula óssea defeituosa por células-tronco saudáveis ​​de um doador aceitável. Procedimentos como a esplenectomia são estratégias de controle dos sintomas e melhoram o estado de saúde dos pacientes.

O tratamento da anemia falciforme (AF) é uma doença hereditária que afeta os glóbulos vermelhos, fazendo com que fiquem tensos e em formato de lua crescente. Consequentemente, o fluxo sanguíneo pode ser bloqueado e pode ocorrer dor. O tratamento é principalmente sintomático, com ênfase na prevenção de complicações da doença. Os episódios de dor são geralmente tratados com hidratação, analgésicos e transfusões de sangue. A hidroxiureia é um medicamento comum eficaz na redução da frequência das crises de dor. Esses pacientes podem ter a opção de transplante de medula óssea ou de células-tronco, uma potencial cura para a AF. Novos tratamentos, como edição genética e/ou tecnologia CRISPR, estão em testes. Consultas regulares e medidas preventivas de saúde serão fundamentais para o manejo eficaz da anemia falciforme.

O tratamento do mieloma múltiplo é um câncer que afeta as células plasmáticas da medula óssea. Os pacientes serão submetidos a testes com diferentes tratamentos para controlar a doença e os sintomas. Os tratamentos de primeira linha podem consistir em uma combinação de quimioterapia, corticosteroides, terapia direcionada e terapias imunomoduladoras, como a lenalidomida. Alguns pacientes podem se tornar candidatos a transplantes de células-tronco, nos quais receberão nova medula óssea para substituir a medula óssea danificada. Bifosfonatos são usados ​​para ajudar a reduzir o risco de danos aos ossos. Alguns dos tratamentos mais recentes incluem terapia com células CAR-T e anticorpos monoclonais. Embora esse câncer seja atualmente classificado como incurável, existem opções de tratamento que estão melhorando a sobrevida e a qualidade de vida de muitos pacientes.

O tratamento do mieloma múltiplo é um câncer que afeta as células plasmáticas da medula óssea. Os pacientes serão submetidos a testes com diferentes tratamentos para controlar a doença e os sintomas. Os tratamentos de primeira linha podem consistir em uma combinação de quimioterapia, corticosteroides, terapia direcionada e terapias imunomoduladoras, como a lenalidomida. Alguns pacientes podem se tornar candidatos a transplantes de células-tronco, nos quais receberão nova medula óssea para substituir a medula óssea danificada. Bifosfonatos são usados ​​para ajudar a reduzir o risco de danos aos ossos. Alguns dos tratamentos mais recentes incluem terapia com células CAR-T e anticorpos monoclonais. Embora esse câncer seja atualmente classificado como incurável, existem opções de tratamento que estão melhorando a sobrevida e a qualidade de vida de muitos pacientes.

O transplante de células-tronco hematopoiéticas (TCTH) é um tratamento aceito para algumas doenças do sangue, incluindo leucemia, linfoma ou doenças genéticas hereditárias. O TCTH ocorre quando células-tronco (pense nas células-tronco do paciente e, possivelmente, de um doador) são transplantadas para o corpo, enquanto parte da medula óssea doente ou danificada é substituída. O TCTH pode ser autólogo (as células-tronco colhidas e criopreservadas do próprio paciente são reintroduzidas) ou alogênico (células-tronco transplantadas de um doador aceitável). Antes do TCTH, o paciente normalmente será submetido a um tratamento de quimioterapia em altas doses ou radiação em altas doses (para destruir a medula óssea doente do paciente), seguido pelo transplante de células-tronco. Com o tempo, as células-tronco crescerão novamente e produzirão células sanguíneas saudáveis/normais para substituir as células sanguíneas doentes, danificadas ou ausentes.

Um tratamento de transfusão de sangue é o processo de dar ao paciente sangue doado através de uma linha (IV). As transfusões de sangue são frequentemente usadas para tratar casos graves de anemia, perda excessiva de sangue após cirurgia ou trauma, e certas doenças do sangue, como hemofilia. Antes que o paciente possa receber sangue, ele será submetido a exames de sangue para garantir a compatibilidade, esses testes podem ser realizados em vários componentes do sangue para garantir que o paciente receba o sangue mais compatível. Todos os componentes do sangue são cuidadosamente combinados com base na pessoa para o tipo sanguíneo (A, B, AB, O) e Rh (+) ou (-). Uma vez que a triagem do sangue é concluída e a transfusão está pronta para ser administrada, o procedimento é concluído sob a supervisão rigorosa do profissional de saúde que monitora de perto o paciente para potenciais reações adversas. As transfusões de sangue são extremamente importantes para salvar vidas e melhorar a qualidade

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