Suboxone vs Methadone: Both opioids can cause withdrawal symptoms, which can increase the risk of dependence for both medicines. Suboxone, which contains buprenorphine and naloxone, has a ceiling effect that may lower the risk of overdose compared to methadone. Methadone, a full opioid agonist, is often more effective for individuals with severe opioid use disorder but carries a higher risk of respiratory depression.