Soma vs Flexeril Compare their differences, benefits, and safety before deciding which muscle relaxant will be right for yoSoma vs Flexeril is a common comparison among muscle relaxants prescribed for acute musculoskeletal pain. While both target the central nervous system, Soma (carisoprodol) is known for its faster onset and stronger sedative effects. Flexeril (cyclobenzaprine) is often preferred for its lower risk of dependence and milder side effect profile. Soma vs Flexeril debates often center on effectiveness versus safety, especially for long-term use. ur pain relief.