Hydrocodone 10-500mg pills typically begin to work within 30 to 60 minutes after taking it by mouth. Most people start to feel pain relief during this time as the medication is absorbed into the bloodstream. Peak effects are usually felt within 1 to 2 hours, depending on factors such as metabolism, whether it was taken with food, and individual body response. The duration and strength of relief can vary from person to person, so it should always be used as directed by a healthcare professional.