Oxycodone Vs Dilaudid: Which Pain Medication Works Better? https://nuheals.com/oxycodone-vs-dilaudid/ Oxycodone and Dilaudid are both opioid pain relievers used for moderate to severe pain. Dilaudid is stronger and works faster than oxycodone, while oxycodone is more commonly used and available in oral tablet form. Both act on the brain to reduce pain but require careful use due to their strength.