https://nuheals.com/gabapentin-vs-duloxetine/ Gabapentin and duloxetine are both used to treat nerve pain, but they work differently. Gabapentin calms overactive nerves and is often used for nerve-related pain and seizures, while duloxetine is an antidepressant that helps pain by balancing brain chemicals linked to mood and pain signals. Gabapentin commonly causes drowsiness, while duloxetine may cause nausea or dry mouth.