https://nuheals.com/percocet-vs-morphine/ Percocet and morphine are both strong opioid painkillers, but they differ in strength and use. Percocet combines oxycodone with acetaminophen and is typically used for moderate to severe pain, often short-term. Morphine is a more potent opioid, used for severe or chronic pain, and can be given orally, intravenously, or via other medical routes. Morphine is generally stronger and requires closer medical supervision.