https://nuheals.com/vicodin-vs-hydrocodone/ Vicodin and hydrocodone are closely related, but they are not exactly the same. Hydrocodone is the opioid pain-relief ingredient, while Vicodin is a brand-name medication that combines hydrocodone with acetaminophen. Both are used for moderate to severe pain, but Vicodin includes the added pain-relief effect of acetaminophen along with hydrocodone.