The simplest way to speak with a live person is by calling our QuickBooks Enterprise Support number. QuickBooks' main line is 1-877-243-6445 [US Support] (Live Agent). When you call, you’ll be connected to a live representative who can assist with billing, account management, software support, and more. How Do I Contact QuickBooks Enterprise Support by Phone? The main QuickBooks Enterprise Support number is 1-877-243-6445 or +1-877-243-6445, where you can reach a live representative 24/7.