Shop Now: https://cosmodix.com/pain-relief/vicodin/vicodin-5-500-mg/ --- Vicodin is a combination of Acetaminophen and Hydrocodone. Hydrocodone, an opioid pain medicine, is available in the United States. Opioids are sometimes referred to as narcotics. Acetaminophen, a less potent pain reliever, increases the effects produced by hydrocodone.