​Tramadol is an opioid drug that reduces pain perception by attaching to receptors in the brain. It is a powerful analgesic that relieves pain by changing how the brain and nerve system respond to pain. Tramadol comes in two formulations: immediate-release and extended-release. Immediate-release Tramadol is administered every 4 to 6 hours, whereas extended-release is administered every 24 hours. Tramadol is distinct in that it relieves pain without inducing sleepiness or sedation.