Hydrocodone 5-325 and 10-325mg is a combination tablet containing hydrocodone bitartrate (5 mg), an opioid pain reliever, and acetaminophen (325 mg), a non-opioid pain reliever and fever reducer. It is a prescription medication used to manage moderate to severe pain when other treatments are inadequate. Hydrocodone 10/325mg works in the brain to decrease the feeling of pain, while acetaminophen also helps relieve pain and can reduce fever.