Oxycodone and Tylenol (acetaminophen) are often combined in prescription medications to provide stronger pain relief. Oxycodone works as an opioid analgesic, reducing pain signals in the brain, while Tylenol lowers fever and relieves discomfort through a different mechanism. Together, they deliver enhanced effectiveness for moderate to severe pain. Because this combination increases risks of side effects and dependency, it should only be taken under strict medical supervision.