Order Here-Lortab Online Lortab is a brand-name, combination medication containing hydrocodone (an opioid) and acetaminophen (an analgesic). It helps manage pain for people who don't get enough relief from non-opioid medicines. Lortab (hydrocodone/acetaminophen) comes as tablets and syrup that are taken by mouth. Common side effects include sleepiness and dizziness.