Visit Now: https://bigpharmausa.com/norco-vs-vicodin/ Norco and Vicodin are both prescription medications that combine hydrocodone, an opioid pain reliever, with acetaminophen, a non-opioid analgesic. They treat moderate to severe pain but differ slightly in their formulations. Norco generally has a lower amount of acetaminophen compared to Vicodin, with common Norco formulations containing 325 mg of acetaminophen per tablet, while Vicodin formulations often contain 500 mg.