Lortab 5/325 mg is a combination medication containing Hydrocodone (5 mg), an opioid pain reliever, and Acetaminophen (325 mg), a non-opioid pain reliever. It's commonly prescribed to treat moderate to severe pain, typically after surgery or for chronic pain conditions. Hydrocodone works by altering the way the brain and nervous system respond to pain, while Acetaminophen enhances its effects.