Although, your health condition may impact your everyday life, do not let it define who you are.” VICODIN, a hydrocodone and acetaminophen combination, is used to relieve moderate to moderately severe pain. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.