Ritalin VS Adderall: What’s The Difference ,Stimulants such as Ritalin (methylphenidate) and Adderall (amphetamine/dextroamphetamine) are used in the treatment of attention deficit hyperactivity disorder. Ritalin is quick-acting, lasting three to four hours; while Adderall has a therapeutic duration of four to 12 hours, depending on the formulation. Ritalin blocks reuptake of dopamine and norepinephrine, while Adderall promotes release and blocking reuptake. Adverse effects vary somewhat such that there may be headaches with Ritalin, with Adderall increasing heart rate. Individual response varies; therefore, dependence falls on personal needs and physician recommendations.